Diastolic failure: Pathophysiology and therapeutic implications
نویسندگان
چکیده
منابع مشابه
Therapeutic implications of diastolic dysfunction in heart failure.
The idea that diastolic dysfunction may give rise to symptoms of cardiac disease independent of any impairment of systolic function is not new, and was appreciated centuries ago.2 Traditional definitions of heart failure have focused on abnormalities of systolic or pump function ofthe heart, emphasizing the failure of cardiac output to meet the metabolic requirements of the body at peak workloa...
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Systolic and diastolic myocardial dysfunction has been demonstrated to be associated with an activation of the circulating and local renin-angiotensin-aldosterone system (RAAS), and with a subsequent inappropriately increased production of reactive oxygen species (ROS). While, at low concentrations, ROS modulate important physiological functions through changes in cellular signalling and gene e...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1993
ISSN: 0735-1097
DOI: 10.1016/0735-1097(93)90850-z